Key link uncovered between C9orf72 mutation and TDP-43 pathology in ALS/FTD
In a new study, a team of Packard scientists identified a key intersection between two major pathways of…
Legacy of Terror and Hope
For people with inherited forms of ALS, learning of their genetic predisposition can feel like a “death sentence.”…
Answer ALS Launches ‘The Data is Here’ Campaign to Announce the Release of the World’s Largest Open-Sourced ALS Data Portal
Answer ALS Launches ‘The Data is Here’ Campaign to Announce the Release of the World’ Largest Open-Sourced ALS…
Answer ALS Partners to Launch the ‘End ALS Challenge’ Digital Competition
Administered by Kaggle, the End ALS Challenge asks participants to help identify solutions to the disease NEW ORLEANS,…
Packard scientists have identified a new mechanism by which mutations in the UBQLN2 gene lead to ALS
Teams from the University of Maryland and Harvard University have showed that ALS-linked mutations in UBQLN2 compromise import…
Packard team identifies a new mechanism through which mutant FUS can lead to ALS
A team of Packard-funded scientists, led by Udai Pandey and Chris Donnelly at the University of Pittsburgh, have…
How AI is helping improve the healthcare experience – three use cases
Using AI to leverage the data in healthcare organisations will have a positive impact on both patient care…
ALS Pathology Linked to Defects in the Cell Nucleus
Packard researchers used Answer ALS cell lines to show that the protein CHMP7 accumulates in the nucleus, triggering…
Researchers Show How Repeat Sequences in ALS Gene Produce Disease
Researchers identify how the repeat sequence at the front of C9ORF72, a gene closely associated with ALS, can…
Overactive Microglial Pruning linked to Defective C9orf72 Gene in Neurodegenerative Diseases
Researchers identify how C9orf72 triggers inflammation and age-dependent neural defects that affect learning and memory. Defects in the…