Project: Characterizing IL-18 PathwayInhibitors as Therapeutics for ALS
Institution: Weizmann Institute of Science
Project: Dissecting the Molecular Determinants of Cytoplasmic Gain of Function Pathomechanisms in TDP - 43 - linked Amyotrophic Lateral Sclerosis
Institution: King’s College, London
Project: Alternative polyadenylation is a key feature of transcriptome dysregulation in ALS.
Institution: University of California Irvine
Project: TDP-43 mutations and lysosomal proteolysis
Institution: University of California San Francisco
Project: Using the Answer ALS Dataset to Expand Genetically Defined ALS Subtypes
Institution: Washington University
Project: RNA processing by TDP-43 during stress
Institution: University of Massachusetts Chan Medical School
Project: Microglia regulation of selective neuronal vulnerability associated with amyotrophic lateral sclerosis (ALS)
Institution: Oregon Health & Science University
Project: Identify TDP-43 dependent, muscle specific alterations in new protein synthesis, in vivo
Institution: Penn State University
Project: Defining how poly(ADP-ribose) enables formation of neurotoxic TDP-43 conformers.
Institution: University of Pennsylvania
Project: Investigating NEK1 haploinsufficiency in human motor neurons
Institution: Northwestern University