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      • The Packard Center consists of a group of committed scientists who tackle key questions related to the cause and treatment of ALS. To support their studies, the Center provides expertise, advanced technology, and a highly collaborative spirit.

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Packard Logo 25 Years
Stephanie Moon, PhD
Project: Regulation of Stress Granules in Wild-type and VCP Mutant Neurons
Institution: University of Michigan
Claire Clelland, MD, PhD
Project: CRISPR gene therapy for C9orf72 FTD/ALS
Institution: University of California San Francisco
John Landers, PhD
Project: Development of Mutant Specific ASOs for TDP-43 and KIF5A
Institution: University of Massachusetts Chan Medical School
Adrian Isaacs, PhD
Project: Lipid desaturase overexpression to ameliorate neurodegeneration in C9orf72 repeat mice
Institution: University College London
Michael Coleman, PhD
Project: Compensatory effects preventing SARM1-dependent neuron and axon death (Project Renewed)
Institution: The Chancellor Masters and Scholars of the University of Cambridge
Daryl Bosco PhD
Project: Investigating stress response mechanisms in human ALS-TDP neurons (Project Renewed)
Institution: University of Massachusetts Chan Medical School
Bahareh Ajami, PhD
Project: Microglia regulation of selective neuronal vulnerability associated with amyotrophic lateral sclerosis (ALS) (Project Renewed)
Institution: Oregon Health & Science University
Payam Mohassel, MD
Project: Cellular and animal models of SPTLC1-related juvenile ALS
Institution: Johns Hopkins University
Luc DuPuis, PhD
Project: Consequences of NUP50 mutation or loss of function in amyotrophic lateral sclerosis
Institution: INSERM (Strasbourg, France)
Eran Hornstein, MD, PhD
Project: Characterizing IL-18 PathwayInhibitors as Therapeutics for ALS
Institution: Weizmann Institute of Science (Rehovot, Israel)
Marc-David Ruepp, PhD & Sarah Mizielinska, PhD
Project: Dissecting the Molecular Determinants of Cytoplasmic Gain of Function Pathomechanisms in TDP - 43 - linked Amyotrophic Lateral Sclerosis
Institution: King’s College, London
Albert LaSpada, MD, PhD, FACMGG
Project: Alternative polyadenylation is a key feature of transcriptome dysregulation in ALS.
Institution: University of California Irvine

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